Physiology and pathophysiology of the mesangial cell
نویسنده
چکیده
The intercapillary area of the kidney glomerulus was first described and named «mesangium» by Zimmermann in 1933 1. The advent of electron microscopy enabled Marinozzi in Italy 2 and Latta in the U.S. 3 to conclusively demonstrate that a separate cell type exists in the kidney glomerulus, in addition to epithelial and endothelial cells lining around the basement membrane. The functions of these «mesangial» cells have been subsequently elucidated, based on recognition of their contractile phenotype and involvement in a variety of glomerular diseases (table I) 4-7.
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